Ketamine Therapy in Irvine, CA
Physician-supervised, in-clinic ketamine injection therapy for depression, anxiety, PTSD, and chronic pain — with transparent pricing and continuity of care from a team that knows your full health picture.
Important: Ketamine is approved by the FDA as an anesthetic. Its use for depression, anxiety, PTSD, and chronic pain is considered off-label, meaning the FDA has not approved it for these conditions. Off-label prescribing is legal and common in medicine when supported by clinical evidence and physician judgment. We will discuss this with you in detail before treatment.
Who This Is For
Ketamine therapy is one option among several for people who haven't found relief with other approaches. It isn't the right fit for everyone.
We treat
- Treatment-resistant depression
- Major depressive disorder
- Anxiety disorders
- PTSD
- Chronic pain conditions
May not be right for you if
- History of psychosis or certain psychotic disorders
- Uncontrolled cardiovascular disease
- Pregnancy
- Active, unmanaged substance use disorder
- Certain uncontrolled medical conditions identified during screening
A full medical and psychiatric history is reviewed during your consultation to determine whether ketamine therapy is appropriate for you.
What ketamine is, in plain language
Ketamine is a medication that has been used safely in medical settings as an anesthetic for decades. Over the past two decades, researchers have studied its effects at lower doses on mood and pain, publishing findings in peer-reviewed psychiatric and anesthesiology journals.
Unlike traditional antidepressants, which can take weeks to have an effect, ketamine acts on a different pathway in the brain and may produce changes in mood more quickly for some patients. Response varies by individual, and ketamine is not effective for everyone.
Ketamine therapy is typically considered for patients who have tried other treatments — such as therapy or standard medications — without adequate relief, in consultation with a physician.
What a Session Looks Like
Knowing what to expect is often what makes the first step easier.
Arrival & Screening
You'll check in, and our clinical team will review your health history, current medications, and vitals before every session.
Vitals & Preparation
Blood pressure and heart rate are checked and monitored. Your care team will answer any last questions before starting.
The Treatment
Ketamine is administered by injection in a private, monitored treatment room. A clinician remains available throughout the session.
Recovery & Monitoring
You'll rest in the treatment room under observation until your care team confirms you're ready to be discharged.
Getting Home
You will need a driver. Ketamine affects coordination and judgment, and you may not drive for 24 hours after treatment.
Plan ahead: You will need a driver to take you home after every session, and you may not drive for 24 hours afterward.
Our Protocol
Induction Phase
Weekly sessions for approximately 8 weeks, allowing your care team to monitor your response and adjust your plan.
Maintenance Phase
Monthly sessions thereafter, adjusted based on your individual response and goals in consultation with your physician.
Every protocol is individualized. Your exact schedule will be set collaboratively with your care team.
What It Costs
No form to fill out just to see a number. Cash-pay, exact pricing, and a discount if you're already a Rume Health member.
Pricing details coming soon.
Call us for current rates while our pricing page is finalized.
Safety & Risks
We'd rather you know exactly what to expect than find out after you've booked. Every patient is screened individually, and we'll walk through all of this with you before treatment begins.
- Dissociation and perceptual changes during treatment
- Transient increases in blood pressure and heart rate
- Nausea
- A driver is required, and you may not drive for 24 hours after treatment
- Bladder and cognitive effects have been associated with frequent or long-term use
- Ketamine is a Schedule III controlled substance with abuse and dependence potential
- Ketamine is not appropriate for everyone — we screen for contraindications before treatment begins
Your Care Team
Physician-supervised, integrated with the rest of your care at Rume Health.
Matthew Abinante
Supervising Physician, DO
Aeli Hartmann
Completed Ketamine-Assisted Psychotherapy Clinician Training (24.75 AANP-accredited contact hours, 2022).
Frequently Asked Questions
In crisis right now?
Ketamine therapy is not an emergency or crisis service. If you or someone you know is in crisis, help is available right now, free and confidential.